Aug
TL;DR: Faces don’t age in one layer. They age in five: bone, fat pads, collagen and elastin, surface, and muscle movement. CT research shows the facial skeleton keeps remodeling for life, fat compartments deflate and descend independently, and total skin collagen declines roughly 1% per year. The 5-Dimension Skin Plan™ is the framework I use to assess all five dimensions before recommending any treatment. The evidence supports thinking this way: in a randomized trial, a neuromodulator plus filler held correction for roughly 32 weeks versus 18 for filler alone. Assess first, sequence second, measure always.
Total skin collagen declines roughly 1% per year across adult life (British Journal of Dermatology, 1975). That number gets quoted a lot, and it’s real. However, collagen is only one of five things changing in an aging face. In my practice in Guelph, the most common frustration I hear isn’t “I look older.” It’s “I had a treatment somewhere and it didn’t look right.” Usually, nothing failed. The treatment simply addressed one layer of a five-layer process. That’s exactly why I built the 5-Dimension Skin Plan™: a structured way to assess bone, fat, collagen, surface, and muscle before recommending anything. It’s also the foundation of our skin longevity approach. Here’s the anatomy behind each dimension, and the evidence for treating them together.
Key Takeaways
- The facial skeleton remodels throughout life: in CT scans of 60 patients, glabellar and maxillary angles decreased significantly with age (Plastic and Reconstructive Surgery, 2007).
- Facial fat sits in discrete compartments that deflate and descend independently (Plastic and Reconstructive Surgery, 2007), which is why single-point filler can look unnatural.
- Total skin collagen declines roughly 1% per year across adult life (British Journal of Dermatology, 1975), and adult elastic fibers are essentially never rebuilt (Journal of Clinical Investigation, 1991).
- Combination treatment outlasted single treatment in a randomized trial: roughly 32 weeks versus 18 before glabellar lines returned (Dermatologic Surgery, 2003).
The 5-Dimension Skin Plan™ is my clinical framework for organizing facial aging into five assessable dimensions: bone, fat pads, collagen and elastin, surface quality, and muscle movement. The anatomy underneath it is well documented. CT research shows the facial skeleton itself keeps remodeling with age (Plastic and Reconstructive Surgery, 2007).
One clarification matters to me. The studies cited in this article describe the anatomy of aging. They don’t test my framework, because the framework is simply how I organize that published evidence into one clinical assessment. Think of it as a lens, not a product.
In a consultation, we grade each dimension separately:
1. Bone resorption, the slow remodeling of your facial skeleton 2. Fat-pad deflation and descent, changes in the face’s volume compartments 3. Collagen and elastin decline, loss of the skin’s structural proteins 4. Surface texture and pigment, largely sun-driven change 5. Muscle-related dynamic lines, expression lines that imprint over time
Consequently, no two plans look alike. Two 55-year-olds can share a birth year and need completely different sequencing.
Facial aging runs deeper than skin. Cadaver research shows facial fat is partitioned into discrete, independently behaving compartments (Plastic and Reconstructive Surgery, 2007), and the skeleton beneath keeps remodeling for life. The 5-Dimension Skin Plan™ groups that evidence into the five dimensions below.
Bone resorption is the gradual loss and reshaping of facial bone, and it never fully stops. In CT scans of 60 patients across age groups, the glabellar and maxillary angles decreased significantly with age (Plastic and Reconstructive Surgery, 2007). Review work describes the same pattern: the orbital aperture widens and the midface retrudes over time (Aesthetic Plastic Surgery).
Why does that matter for how you look? Because the skeleton is the scaffolding. When it recedes, the soft tissue above loses support, and folds deepen without the skin itself changing much. Consequently, some plans include deep structural support and others don’t need it yet. Assessment decides.
Facial fat isn’t one continuous sheet. Cadaver dissections showed it’s partitioned into discrete, independent fat compartments (Plastic and Reconstructive Surgery, 2007). A later imaging study of 12 cadaveric specimens, small but detailed, found the midfacial compartments migrate downward with age while the deep medial cheek fat loses volume (Plastic and Reconstructive Surgery, 2012).
Here’s the clinical takeaway: deep pads deflate, superficial pads descend. That’s why single-point “cheek filler” often looks unnatural. It inflates a pad that’s sliding down instead of restoring the deep support that actually deflated. Meanwhile, a compartment-aware approach places dermal fillers where volume was truly lost, and considers collagen-stimulating options like Sculptra when broader support suits the face better.
Total skin collagen declines roughly 1% per year across adult life. That figure comes from forearm-biopsy research (British Journal of Dermatology, 1975), and its author restated the finding in 2020 (PMC). The production machinery slows too: fibroblasts in aged skin make less procollagen, the raw material of new collagen (American Journal of Pathology62205-5/fulltext), 2006).
Elastin, the protein behind your skin’s snap-back, is a harsher story. Studies of human elastic tissue suggest turnover essentially stops in adulthood; carbon-dating research in lung tissue measured a mean elastin residence of roughly 74 years (Journal of Clinical Investigation, 1991). That measurement comes from lung rather than skin, however it’s the standard reference for how little elastic fiber adults rebuild.
Consequently, prevention beats repair in this dimension. Collagen responds to stimulation, which is where treatments like Morpheus8 radiofrequency microneedling can fit a plan. Damaged elastic fibers, meanwhile, aren’t rebuilt. Protect them.
Solar elastosis is the abnormal elastotic material that replaces normal collagen in sun-damaged dermis, and it’s the histologic hallmark of photoaging (Journal of Cutaneous Pathology, 2003). Under the microscope, sun-aged skin looks different from merely old skin.
At the surface, this dimension shows up as rough texture, uneven pigment, and fine lines. Resurfacing approaches such as the eCO2 laser address it directly, and prevention matters more here than anywhere else. I cover the mechanisms, the sunscreen trials, and the repair evidence in detail in our photoaging guide.
Expression lines start as movement and end as imprint. The clearest illustration I know is a 13-year comparison of identical twins: the twin treated regularly with botulinum toxin had no imprinted at-rest forehead or glabellar lines, while the minimally treated twin did (Archives of Facial Plastic Surgery, 2006). It’s a genetically controlled observation of two people, not trial evidence, so I treat it as illustrative rather than proof.
Still, the mechanism is straightforward. Repeated folding creases skin the way daily folding creases paper. Prescription neuromodulators such as Botox, Dysport, or Xeomin reduce that folding; in my hands, the goal is softer imprinting with preserved expression.
Because the dimensions interact. In a randomized trial of 38 patients, pairing a neuromodulator with hyaluronic acid filler in the glabella maintained correction for roughly 32 weeks, versus 18 weeks with filler alone (Dermatologic Surgery, 2003). Relaxing the muscle protected the filler result: two dimensions, one outcome.
Larger multimodal data points the same direction, with caveats worth naming. In the HARMONY study, patients treated across several modalities saw FACE-Q satisfaction scores rise from 41.2 to 72.9 at month four, and self-perceived age averaged 4.6 years younger than actual age (Aesthetic Surgery Journal, 2018). However, HARMONY was open-label with no control group and was Allergan-affiliated, so I weight it as supportive rather than definitive.
Does that mean everyone needs everything? No. In my experience, the 5-Dimension Skin Plan™ usually produces a shorter list than patients arrive with. It’s a sequencing tool: we identify the one or two dimensions driving what you actually see, treat those first, and reassess before touching anything else.
With standardized imaging, not memory. VISIA-type photographic systems have published reproducibility validation for wrinkle analysis, and absolute scores proved more precise than percentile rankings in that research (Henseler, 2023). Numbers replace “I think it looks better,” which protects you from wishful thinking. Mine included.
Practically, we image at baseline under controlled conditions, then re-image at follow-ups with identical positioning and lighting. We track absolute scores over time rather than chasing percentile comparisons against other people. I wrote more about this in making the invisible visible, our guide to the measurement tools we rely on.
This is also your protection as a patient. If a dimension didn’t measurably change, we talk about why before anyone suggests more treatment.
No. It’s an assessment framework, not a bundle of procedures. The five dimensions come from published anatomy: reviews document lifelong skeletal remodeling, including a widening orbital aperture and midface retrusion (Aesthetic Plastic Surgery). The plan is how I organize that evidence into one structured evaluation. Treatment only follows if the assessment supports it.
There’s no single start date. The facial skeleton remodels continuously, with CT evidence of significant angle changes across adult age groups (Plastic and Reconstructive Surgery, 2007), and total skin collagen declines roughly 1% per year (British Journal of Dermatology, 1975). Consequently, I suggest a baseline assessment whenever changes start bothering you.
No. Topicals mainly help the surface dimension. They can’t restore bone or reposition fat compartments, and adult elastic fibers are essentially not replaced: studies of human elastic tissue measured a mean elastin residence of roughly 74 years (Journal of Clinical Investigation, 1991). Meanwhile, daily sun protection defends proteins you can’t rebuild.
No. Most plans are sequenced over months, and some people only need one dimension addressed. The randomized evidence simply shows pairing helps when appropriate: a neuromodulator plus filler maintained glabellar correction roughly 32 weeks versus 18 for filler alone (Dermatologic Surgery, 2003). We prioritize what’s driving your changes.
With standardized imaging rather than memory. VISIA-type photographic analysis carries published reproducibility validation for wrinkle measurement, and absolute scores proved more precise than percentile rankings (Henseler, 2023). We capture baseline images, repeat them under identical conditions at follow-up, and compare the numbers with you directly.
If part of this article sounded like your mirror, an assessment can show you which dimensions are actually driving it. We’ll map all five, review your imaging together, and sequence only what’s worth doing. Sometimes the honest recommendation is sunscreen, a prescription conversation, and a follow-up photo next year. Request a consultation and we’ll start with the map, not a menu.
Medically reviewed by Dr. Dusan Sajic, MD, PhD — dermatologist, deRMA Skin Institute, Guelph, ON.
1. Shaw RB, Kahn DM. “Aging of the midface bony elements: a three-dimensional computed tomographic study.” Plastic and Reconstructive Surgery, 2007. https://pubmed.ncbi.nlm.nih.gov/17230106/ 2. Mendelson B, Wong CH. Review of facial skeletal changes with aging and their clinical applications. Aesthetic Plastic Surgery (republished 2020). https://link.springer.com/article/10.1007/s00266-020-01823-x 3. Rohrich RJ, Pessa JE. “The fat compartments of the face: anatomy and clinical implications for cosmetic surgery.” Plastic and Reconstructive Surgery, 2007. https://pubmed.ncbi.nlm.nih.gov/17519724/ 4. Gierloff M et al. Aging changes of the midfacial fat compartments (computed tomographic study of 12 cadaveric specimens). Plastic and Reconstructive Surgery, 2012. https://pubmed.ncbi.nlm.nih.gov/21915077/ 5. Shuster S, Black MM, McVitie E. “The influence of age and sex on skin thickness, skin collagen and density.” British Journal of Dermatology, 1975. https://pubmed.ncbi.nlm.nih.gov/1220811/ 6. Shuster S. Author’s 2020 restatement of the skin-collagen decline data. https://pmc.ncbi.nlm.nih.gov/articles/PMC7160787/ 7. Varani J et al. “Decreased collagen production in chronologically aged skin.” American Journal of Pathology, 2006. https://ajp.amjpathol.org/article/S0002-9440(10)62205-5/fulltext 8. Shapiro SD et al. Elastin longevity measured by D-aspartate and radiocarbon in human lung parenchyma. Journal of Clinical Investigation, 1991. https://pubmed.ncbi.nlm.nih.gov/2022748/ 9. Sellheyer K. “Pathogenesis of solar elastosis: synthesis or degradation?” Journal of Cutaneous Pathology, 2003. https://onlinelibrary.wiley.com/doi/full/10.1034/j.1600-0560.2003.00018.x 10. Binder WJ. Long-term botulinum toxin effects on facial lines: a 13-year comparison in identical twins. Archives of Facial Plastic Surgery, 2006. https://pubmed.ncbi.nlm.nih.gov/17116793/ 11. Carruthers J, Carruthers A. Randomized trial of botulinum toxin plus hyaluronic acid versus filler alone for glabellar rhytids (38 patients). Dermatologic Surgery, 2003. https://pubmed.ncbi.nlm.nih.gov/12859378/ 12. HARMONY multimodal aesthetic treatment study (open-label, no control group; Allergan-affiliated). Aesthetic Surgery Journal, 2018. https://pubmed.ncbi.nlm.nih.gov/29244069/ 13. Henseler H. Reproducibility validation of VISIA camera wrinkle analysis; absolute versus percentile scores. 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665717/
Dusan Sajic, MD, PhD
Richard Backstein, MD
Sonja Sajic, CCPA
Toni Alberto, CCPA
With more than 20 years of experience, deRMA Skin Institute strive to offer patients the most advanced treatments available to keep their skin healthy and looking its best. Board Certified Dermatologist, Dusan Sajic, MD, PhD, board-certified Plastic and Reconstructive Surgeon, Richard Backstein, MD, FRCSC, Sonja Sajic, CCPA, and Toni Alberto CCPA are committed to providing state-of-the-art medical, surgical and cosmetic treatments to all patients in Guelph, Cambridge, Kitchener, Hamilton, Milton, and surrounding areas.
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